Complex Regional Pain Syndrome (CRPS) encompasses a condition characterized by persistent pain and inflammation that may arise following an injury, surgery, trauma, stroke, or heart attack. Primarily impacting the arms, legs, hands, or feet, CRPS often develops as a response to trauma or injury in these areas.

CRPS is divided into subtypes: CRPS-1, which occurs after an injury without direct nerve damage, and CRPS-2, associated with specific nerve damage. Most CRPS cases fall into the CRPS-1 category. Additionally, CRPS can manifest as Warm CRPS, typically in its initial stages, or Cold CRPS, which appears in prolonged cases.

For those affected, CRPS symptoms include pain that significantly exceeds the expected level for the visible injury, along with changes in skin color, temperature, and swelling in the affected limb. These symptoms can evolve, altering in pain type, skin color, and temperature.

CRPS may be classified as acute (short-term) or chronic (lasting beyond three months). Initial research suggested a high recovery rate within a year; however, more recent studies indicate that while symptoms may lessen, many individuals continue to experience pain past this timeframe. In its severe or enduring form, CRPS can substantially hinder a person's ability to work or engage in everyday activities, presenting significant challenges for working professionals.